[www.ncbi.nlm.nih.gov]

Myrciaria dubia (HBK) McVaugh (camu-camu) belongs to the Myrtaceae family that is native to the Amazon rainforest. Its fruit is well-studied for its antioxidative activities both in vitro and in vivo through the decrease of reactive oxygen species (ROS) production [1,2,3]. Camu-camu exhibits pharmacological effects on neuroprotection, antihypertension, antimicrobial, anti-proliferation, and anti-genotoxicity activities [4,5,6,7]. These activities are due to the effects of the vitamin C content, promising polyphenols such as gallic acid, quercetin, and ellagic acid, and proanthocyanins such as cyanidin-3-glycoside. These active compounds exhibit various biological properties

Anti-inflammatory [25,26]
Immunomodulatory [27]
Antiallergic [28]
Anticancer [29]
Antioxidative [30]
Anti-diabetes [32]
Antiaging [36]


The camu-camu fruit is a tropical fruit native to the Amazon region and is one of the few Amazon fruits that have been explored for commercial purposes [41]. The phenolic components of the camu-camu fruit include ellagic acid and quercetin which contribute to the pharmacological properties.

The results showed that the camu-camu fruit dose-dependently inhibited mRNA expression of proinflammatory cytokine IL-8 and chemokines MDC, RANTES, and TARC in high-glucose-induced HaCaT cells.

These results suggest that the camu-camu fruit extract exerts great antioxidant activity through upregulation of the Nrf2 signaling pathway.