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Re: eating meat promotes the cancer hormone IGF-1
Posted by: Panchito ()
Date: December 21, 2013 08:50PM

Note: eating vegan protein reduces IGF-1

Extra notes:


Contribution to aging

It is now widely accepted that signaling through the insulin/IGF-1-like receptor pathway is a significant contributor to the biological aging process in many organisms. This avenue of research first achieved prominence with the work of Cynthia Kenyon, who showed that mutations in the daf-2 gene double the lifespan of the roundworm, C. elegans.[12] Daf-2 encodes the worm's unified insulin/IGF-1-like receptor. Despite the impact of IGF1-like on C. elegans longevity, direct application to mammalian aging is not as clear as mammals do not form dauer like developmental stages.

Insulin/IGF-1-like signaling is conserved from worms to humans. In vitro experiments show that mutations that reduce insulin/IGF-1 signaling have been shown to decelerate the degenerative aging process and extend lifespan in a wide range of organisms, including Drosophila melanogaster, mice,[13] and possibly humans.[14][15][16][17] Reduced IGF-1 signaling is also thought to contribute to the "anti-aging" effects of Calorie restriction.[18]"

cancer

The IGF signaling pathway has a pathogenic role in cancer. Studies have shown that increased levels of IGF lead to increased growth of existing cancer cells.[23] People with Laron syndrome have also recently been shown to be of much less risk to develop cancer.[24]

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