Living and Raw Foods web site.  Educating the world about the power of living and raw plant based diet.  This site has the most resources online including articles, recipes, chat, information, personals and more!

Click this banner to check it out!
Click here to find out more!

UV light is addictive
Posted by: Panchito ()
Date: June 21, 2014 07:13PM


"Skin B-Endorphin Mediates Addiction to UV Light


•UV exposure leads to elevated blood levels of B-endorphin in mice
•UV causes systemic analgesia that is reversible with opioid receptor blockade
•Chronic UV causes dependency and “addiction”-like behavior
•Addiction-like behaviors require keratinocyte signaling and B-endorphin expression


UV light is an established carcinogen, yet evidence suggests that UV-seeking behavior has addictive features. Following UV exposure, epidermal keratinocytes synthesize proopiomelanocortin (POMC) that is processed to melanocyte-stimulating hormone, inducing tanning. We show that, in rodents, another POMC-derived peptide, B-endorphin, is coordinately synthesized in skin, elevating plasma levels after low-dose UV. Increases in pain-related thresholds are observed and reversed by pharmacologic opioid antagonism. Opioid blockade also elicits withdrawal signs after chronic UV exposure. This effect was sufficient to guide operant behavioral choices to avoidance of opioid withdrawal (conditioned place aversion). These UV-induced nociceptive and behavioral effects were absent in B-endorphin knockout mice and in mice lacking p53-mediated POMC induction in epidermal keratinocytes. Although primordial UV addiction, mediated by the hedonic action of B-endorphin and anhedonic effects of withdrawal, may theoretically have enhanced evolutionary vitamin D biosynthesis, it now may contribute to the relentless rise in skin cancer incidence in humans."

Options: ReplyQuote
Re: UV light is addictive
Posted by: John Rose ()
Date: June 21, 2014 07:48PM

<<<UV light is an established carcinogen now may contribute to the relentless rise in skin cancer incidence in humans.>>>

BULL $#!&!!!

Options: ReplyQuote

Sorry, only registered users may post in this forum.

Navigate Living and Raw Foods below:

Search Living and Raw Foods below:

Search for:

Eat more raw fruits and vegetables

Living and Raw Foods Button
All Rights Reserved


Privacy Policy Statement

Eat more Raw Fruits and Vegetables