Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy
Conclusions: Our study identified 10 genes with newly established links to maternal smoking. Further, we note differences between smoking-related methylation changes in newborns and adults, suggesting possible distinct effects of direct versus indirect tobacco-smoke exposure as well as potential differences due to age. Further work would be needed to determine if these small changes in DNA methylation are biologically or clinically relevant. The methylation changes identified in newborns may mediate the association between in utero maternal smoking exposure and later health outcomes.