The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
arugula
()
Date: February 15, 2015 11:46AM This very well-done study found that high carbohydrate is the way to go:
Solon-Biet et al., The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice Cell Metabolism 19, 418–430, March 4, 2014 The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin (mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation. Diets that were low in protein and high in carbohydrate (i.e., those that promoted longest life) were associated with lower blood pressure (Figures 5C and 5D), improved glucose tolerance (Figure 6A), higher levels of high-density lipoprotein (HDLc; Figure 6, reduced levels of low-density lipoprotein (LDLc; Figure 6C), and lower triglycerides (Figure 6D). This is consistent with human data suggesting that long-term adherence to highprotein, low-carbohydrate diets is linked with increased cardiovascular disease (Floegel and Pischon, 2012; Lagiou et al., 2012) and indicates that the balance of protein to carbohydrate, rather than energy intake, may be the driver of a healthy cardiometabolic profile. The balance of macronutrients, in particular the protein: carbohydrate ratio, had a marked effect on longevity and latelife health. As the protein:carbohydrate ratio increased, there were concomitant increases in hepatic mTOR activation, apparently associated with the combination of elevated circulating BCAAs and low glucose. Given the evidence that activation of mTOR is proaging (Burnett et al., 2011; Fontana et al., 2010; Kapahi et al., 2010), our results support this as a mechanism to explain the life-extending effects of a low-protein, high-carbohydrate diet. epidemiological studies have shown that low-protein, high-carbohydrate diets are associated with improved health in humans (Floegel and Pischon, 2012; Lagiou et al., 2012), which is consistent with our overall conclusions. Our results show that healthy aging is not achieved in mice fed high-protein diets and/or diluted diets to reduce calorie intake, but rather by low-protein diets (especially, we might predict, those low in BCAAs), where additional energy requirements are met by dietary carbohydrates rather than fats. [www.cell.com] Edited 1 time(s). Last edit at 02/15/2015 11:51AM by arugula. Re: The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
SueZ
()
Date: February 15, 2015 12:46PM My lipid panel improved once I got off RAW high carbs/low protein and went to a RAW high fat/low protein diet. Re: The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
arugula
()
Date: February 15, 2015 12:53PM Re: The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
RawPracticalist
()
Date: February 15, 2015 01:29PM What kind of carbohydrates? Raw ? Cooked? Fruits? Vegetables? Re: The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
arugula
()
Date: February 15, 2015 01:44PM Diets varied in content of P (casein and methionine), C (sucrose,
wheatstarch and dextrinized cornstarch) and F (soya bean oil). All other ingredients were kept similar. Other ingredients include cellulose, a mineral mix (Ca, P, Mg,Na, C, K, S, Fe, Cu, I, Mn, Co, Zn, Mo, Se, Cd, Cr, Li, B, Ni and V) and a vitamin mix (vitamin A, D3, E, K, C, B1, B2, Niacin, B6, pantothenic acid, biotin, folic acid, inositol, B12 and choline) supplemented to the same levels as AIN-93G. We already know that mice on whole foods diets live longer than mice on purified diets. In this diet they kept all ingredients the same but varied the proportions. From another study (Newberne and Suphakarn, Nutrition and Cancer 5:107, 1983) Comparing rats fed on semisynthetic and whole foods diets: Type of cancer % of rats with tumors on semisynthetic diet % of rats with tumors on whole foods diet breast 91% 33% liver 67%-96% 29%-48% colon 67% 42% ovary and uterus 67% 11% Re: The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
SueZ
()
Date: February 15, 2015 02:56PM SueZ Wrote:
------------------------------------------------------- > My lipid panel improved once I got off RAW high > carbs/low protein and went to a RAW high fat/low > protein diet. P.S. Triglycerides were not the only thing in my lipid panel that the hclf diet was revealed to have screwed up. There were plenty of *'s in my other lab work as well. I am glad that I get yearly lab work done and hope others will, too. Things can go south before you become aware of it and while you are still feeling good. Re: The Ratio of Macronutrients Dictates Cardiometabolic Health
Posted by:
fresh
()
Date: February 15, 2015 02:57PM SueZ Wrote:
------------------------------------------------------- > My lipid panel improved once I got off RAW high > carbs/low protein and went to a RAW high fat/low > protein diet. any health issues at all? how good is your ability to exercise/perform sport? what is your bodyweight? Sorry, only registered users may post in this forum.
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