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I have studied the Vitamin B12 issue thoroughly, and have learned that biochemists, neutraceutical scientists, and many writers mistakenly use the term Vitamin B12 for cyanocobalamin, THAT IS NOT USABLE BY THE BODY BUT which is in all vitamin B12 supplements. When speaking of Vitamin B12 they are referring to the semisynthetic Vitamin B12 (cyanocobalamin) that initially as contaminated with poisonous cyanide during its chemical extraction from animal tissues. Carbon columns are used during the extraction process and the carbon combines with nitrogen from the medium forming the poisonous cyanocobalamin, that scientists insist on calling Vitamin B12. The original method used to extract Vitamin B 12 from its sources included heating the medium in a weak acid, the addition of cyanide ion, and exposure to light. In this process the coenzymes were converted to cyanocobalamin, yet this was over looked. (Review of Physiological Chemistry, Harper, Harold A., Lange Medical Publications, New York, 1977, page l81. Also refer to Cobalamin: Biochemistry and Pathophysiology, Wiley. N. and F. Sicuteri, New York, 1972.) MOREOVER, in the manufacture of vitamin supplements, cyanide is added to the medium because the carbon and nitrogen are needed to form large molecules as are found in vitamins; and IN ADDITION they need it to extract the B12 from fermentation liquors and liver homogenates. Carbon is needed in great quantities when making vitamins or any other manufactured vitamin or substance that mimics the natural vitamin that normally contains a lot of carbon.

THE TWO VITAMIN B12 COENZYMES KNOWN TO BE METABOLICALLY ACTIVE IN MAMMALIAN TISSUES ARE 5-deoxyadenosylcobalamin and methylcobalamin (methyl-B12). When extracted in light, these two coenzymes undergo photolysis and are destroyed. Natural B12 is found solely in plants and animals, and that is the only form that can be called “coenzyme B12.” If an animal or individual is given cyanocobalamin the body removes the cyanide because it is not usable as a coenzyme and it is toxic. Then the cobalt of the former cyanocobalamin can combine with other substances that are not toxic and actually form Vitamin B12 coenzymes that are usable by the body. These normally existing Vitamin B12 coenzymes are labile and break down easily unless inside living tissue.

Potassium in the body can react with the cyanide found in cyanocobalamin – the “Vitamin B 12” – and form toxic potassium cyanide (KCN). Potassium cyanide is a poisonous compound used as a fumigant. This is one reason why the body jettisons the “Vitamin B 12” (i.e., cyanocobalamin) injections so rapidly. Within 24 hours most (about 90%) of the cyanocobalamin in supplements has been eliminated.

The names of cobalamins formed by the body or in a laboratory are: l. hydroxocobalamin if it combines with a hydroxyl ion (OH), and 2. aquocobalamin, when it combines with water. Cobalamin also combines with anions such as nitrite a form of nitrogen, chloride, and sulfur. These are not usable by the body. The two active coenzymes that can be formed in the body after stripping off the cyanide are 5’deoxyadenosylcobalamin, or adenosylcobalamin for short, and methylcobalamin. The problem is that the cyanide is toxic and makes many people sicker than they were before taking the supplement.

Cyanocobalamin is in every vitamin B12 supplement known because it is stable and less costly to manufacture. But it is not usable in the body. If the body has sufficient energy it may be able to offload the cyanide and benefit from the useful component. Mainly, what people experience after taking cyanocobalamin supplements is stimulation. The toxic effect of the cyanide triggers a rush of energy as the body works hard to excrete the poison, and this fools people into believing that the supplement has “worked” to heal them. Meanwhile, if their blood tests show an increase in B12, it mainly reflects the amount of the CYANOCOBALAMIN in the blood stream. The usable forms are carried into the cells and can’t be discovered by testing the blood as is the current practice. Blood tests are often inaccurate and, as previously stated, in the case of cyanocobalamin supplementation and B12 injections, about 90 % of it has been eliminated from the body in 24 hours.

Looking at it Hygienically, no Vitamin B12 therapy can cause a recovery from any so-called eficiency disease. It may only hide the symptoms and cannot give an individual health. When people report that their apparent B12 deficiency symptoms have been relieved by cyanocobalamin supplementation, they are mistaken. They are not getting usable Vitamin B12 coenzymes, and their bodies are forced to convert the cyanide form into the active forms, methylcobalamin, and adenosylcobalamin. This extra function stimulates but wastes nerve energy, and they are are actually getting worse, not better. They have not addressed the cause of their troubles.

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Having said this, we must bear in mind that many vegetarians and vegans still take antibiotics or consume antibiotic-containing foods such as onions, garlic, strong radishes and other foods rich in mustard oil, which are lethal to intestinal flora. The trouble is that once we have damaged our intestinal flora, it is difficult to correct without proper and knowledgeable healthcare and dietary advice. It is of far greater importance to correct intestinal flora problems than to spend our lives relying on so-called supplements. People who have a physical problem because they think they are not getting enough vitamin B12, are in fact often not digesting, absorbing or assimilating their foods properly because of the condition of their gastrointestinal tract. When their intestines are healed, vitamin B12 can be utilized and produced once again

B12 synthesis is known to occur naturally in the human small intestine (in the ileum), which is the primary site of B12 absorption. As long as gut bacteria have cobalt and certain other nutrients, they produce vitamin B12. Dr Michael Klaper argues that vitamin B12 is present in the mouth as well and intestines. Furthermore, Dr Virginia Vetrano states that active Vitamin B12 coenzymes are found in bacteria in the mouth, around the teeth, in the nasopharynx, around the tonsils and in the tonsilar crypts, in the folds at the base of the tongue, and in the upper bronchial tree. Absorption of the natural B12 coenzymes can take place in the mouth, throat, oesophagus, bronchial tubes and even in the upper small intestines, as well as all along the intestinal tract. This does not involve the complex enzyme mechanism for absorption (Intrinsic Factor) in the small intestine as required by cyanocobalamin. The coenzymes are absorbed by diffusion from mucous membranes (11).