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Researchers Crack Code

6 feet of DNA spooled tightly into every cell in our bodies has a harder time releasing itself as needed

with age, DNA is no longer as flexible as it used to be

The stiffness is due to HDAC3 compacting the DNA material too hard

Removing HDAC3 restores flexibility

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Taken together, the studies suggest that HDAC3 is up-regulated in response to a high fat diet.

HDAC3 has been shown to contribute to hyperglycemia

KNOWN BENEFICIAL FOODS

Inhibitory effects of sulforaphane on HDAC activity may also contribute to its anti-cancer activities.

Sulforaphane is an isothiocynate that can be found in cruciferous vegetables such as broccoli, cabbage, and kale [53].

Curcumin is a polyphenol found in the popular spice turmeric.

Curcumin appears to be beneficial for the prevention of high-fat induced metabolic syndrome.

A major problem with the use of curcumin for the prevention of metabolic syndrome is its bioavailability. Curcumin is poorly bioavailable due to its low absorption in the intestine [71].

Green tea is an ancient beverage derived from the plant Camellia sinensis.

Green tea polyphenols (GTP) have been shown to reduce HDAC activity

Green tea polyphenols, in particular, EGCG appears to be an inhibitor of HAT activity.

the major source of butyrate is from the fermentation of dietary fibers

The gut microbiota is responsible for the formation of short chain fatty acid (SCFA) through the fermentation of dietary fibers.

butyrate inhibited HDAC3 activity

butyrate appears to involve the inhibition of HDAC3 activity in the liver